Four novel Polyhedral Oligomeric Silisesquioxane (POSS) particles were tested for biocompatibility for a promising application in anti-cancer drug delivery. We previously investigated the interference of the four POSS particles and others particles with MTT and crystal violet assay. The interference of these particles was correlated to some of the physical and chemical properties. Toxicity of the four POSS particles seems to be a shape or size dependent. At 100 nm size in diameter, only Trisilanol Isooctyl POSS interrupted the metabolic activity also reduce relative cell number of HaCaT cell line. The other POSS particles did not show any sign of toxicity in both assays although particles were at the same concentrations. Trisilanol Phenyl, Cyclopentyl and Cyclohexal POSS particles could be a potential platform for anti-cancer drug delivery.
Key words: polyhedral oligomeric silisesquioxane, POSS, nanocarriers, toxicity, HaCaT, anti-cancer, drug delivery