Objective: The present study was conducted to determine the hypoglycemic and antioxidant potential of polyherbal formulation in alloxan induced diabetic rats.
Study Design: In five different groups an aqueous suspension of herbal mixture containing equal amounts of Azadirachta indica, Gymnema sylvestre, Momordica charantia, Syzigium cumini, Trigonella foenum was administered orally once a day at a dose of 500 mg/kg body weight for 4 weeks. In these groups lipid peroxidation, reduced glutathione, glutathione S -transferase was estimated in brain and kidney and compared statistically.
Results: There was a significant increase of 27% and 80% in LPO in the brain and kidney respectively, in diabetic animals. The herbal and standard drug treatment decrease LPO level up to control group. GSH level decreased by 34% and 48% in brain and kidney of diabetic group which was restored after herbal and glibenclamide treatment. There was no significant change in GST level in diabetic and herbal treated groups in brain while diabetic group showed reduced GST level in kidney which was raised to normal level with herbal as well as standard drug treatment.
Conclusion: Polyherbal formulation appeared to be safe and effective in diabetes and also have antioxidant potential.
Key words: Azadirachta indica, Gymnema sylvestre, Momordica charantia, Syzigium cumini, Trigonella foenum, Diabetes mellitus, antioxidants
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