Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

J. Islam. Int. Med. Coll.. 2017; 12(2): 92-96


Efficacy of EPI-OFF and EPI-ON Collagen Cross-Linkage Procedure in Terms of Visual Acuity and Astigmatism in Keratoconus Patients

Sumaira Amir, Aamir Asrar.

Abstract
Objective: To compare the efficacy of epi-off and epi-on collagen cross-linkage procedure in terms of visual
outcomes and astigmatism during one-year period.
Study Design: Prospective study.
Place and Duration of Study: Amanat Eye Hospital from May 2014 to April 2015.
Materials and Methods: Eighty patients (102 eyes) with keratoconus were included in this study. There were
forty patients (51 eyes) presented with epi-on collagen cross-linkage procedure (Group I) and forty patients (51
eyes) with epi-off collagen cross-linkage procedure (Group II). Epi-off procedure involved epithelial removal
comprised of isotonic riboflavin solution 0.1% with 20% dextran, whereas epi-on procedure involved intact
epithelium utilized hypotonic 0.25% riboflavin solution.
Results: In Group I, the mean age of patients was 21.83 years± 3.83 SD. There were 27 (67.5%) male and 13
(32.5%) female patients. In Group II, the mean age of patients was 20.75years ± 4SD. There were 22 (55%) male
and 18 (45%) female patients. Uncorrected visual acuity improved to 0.04 Log MAR in epi-on and 0.03 Log MAR
in epi-off procedure with p-value=0.7(statistically insignificant), whereas best corrected visual acuity improved
to 0.06 Log MAR in epi-on and 0.02LogMAR in epi-off technique with p-value=0.28 (statistically insignificant)
respectively. However, mean pre-operative topographic astigmatism were (5.51± 2.58) with epi-on procedure
and (3.98 ±2.30) with epi-off procedure, improvement of mean post-topographic astigmatism were improved
in epi-on procedure (5.10 ±2.42) than epi-off procedure (3.96± 2.20).
Conclusion: There was insignificant difference between both cxl procedures. However, improvement of mean
topographic astigmatism were observed in epi-on as compared to epi-off collagen cross linkage procedure.

Key words: Epi-On CXL, Epi-Off CXL, Keratoconus, Riboflavin



Share this Article


Advertisement
Journal of Environmental and Occupational Science

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.