ABSTRACT
Objectives: Many cancers overexpress GSTP1 which contributes to multidrug resistance via conjugation of antineoplastic drugs. The aim of this paper is investigate the in vivo interaction of GSTP1 and Lfcin B in swiss albino female mice induced with skin cancer using 7, 12 dimethylbenz (a) athracene
Material and Methods: Group B and C received topical application of DMBA, whereas group C was subcutaneously injected with 200μl (20μg/μl) LfcinB while keeping group A as control. The activity of GSTP1 in all the groups were then estimated spectrophotomterically at 340nm by taking the increase in absorbance of GS-DNB conjugate.
Result: Administration of 200μl (20μg/μl) Lfcin B three times per week was found to significantly (p
Key words: In vivo, GSTP1, Lfcin B, Tumor, Skin Cancer, Enzyme Inhibition
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