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Ameliorative Effects of Methanolic Extract of Ficus exasperata (Vahl.) on Carbon Tetrachloride-Induced Hepatopathy in Albino Rats

Akindele Oluwatosin Adeyi, Blessing D Akwarandu, Esther Olubisi Adeyi.

Abstract
This study investigated the ameliorative potentials of methanol leaf extract of Ficus exasperata against CCl4 induced hepatopathy in rats. Thirty adult male wistar strain albino rats divided into five treatments and one control groups were used for the study. Hepatopathy was induced in four of the experimental groups (Group B-E) by a single intraperitoneal injection of 0.4ml of CCl4 dissolved in paraffin wax. Groups B-D were thereafter treated with 100, 200 and 300mg/kg of the extract daily for seven days while Group E was the positive control. Administration of CCl4 induced hepatopathy in all exposed rats as indicated by significantly higher (p

Key words: Carbon Tetrachloride, hepatopathy, liver enzymes, antioxidant profile, Ficus exasperata, ameliorative



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