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Original Article

J App Pharm Sci. 2016; 6(12): 110-113


Effect of intensive endurance training on rat brain and hepatic 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine levels

Mohammad Esmaiel Afzalpour, Hossein TaheriChadorneshin, Seyed-Hosein Abtahi-Eivary, Ehsan Afroozi-Gerow.

Abstract
Aims: The purpose of this study was to investigate the effect of intensive endurance training on 8-oxoguanine DNA glycosylase (OGG1) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in liver and brain of rats.
Materials & Methods: 16 adult Wistar albino rats were randomly divided into sedentary control and endurance exercise training groups. Animals ran on treadmill for 6 weeks, 6 days a week, at at a speed of 10 m/min (85 percent of maximal oxygen consumption). The content of OGG1 and 8-OHdG were measured using sandwich ELISA assay. Data analyzed using Studentís T-test at P‚ȧ0.05 level.
Findings: our results showed that intensive endurance training has no significant effect on 8-OHdG contents in liver (t14=1.09, p=0.29) and brain (t14=0.93, p=0.36) of rats. However, contents of OGG1 in liver (t14=5.84, p=0.001) and brain (t14=4.09, p=0.001) of rats significantly increases following intensive endurance training. Finally, there were no significantly differences between changes in contents of 8-OHdG (t14=0.44, p=0.66) and OGG1 (t14=1.72, p=0.10) in liver and brain of rats following endurance training.
Conclusion: intensive endurance training maintains 8-OHdG genomic damage in baseline level in liver and brain of rats by increasing contents of OGG1.

Key words: Endurance training, 8-oxoguanine DNA glycosylase, 8-hydroxy-2'-deoxyguanosine, Liver, Brain



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