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Original Article

J App Pharm Sci. 2016; 6(11): 191-198


Antifungal activity of the cyanobacterium Microcystis aeruginosa against mycotoxigenic fungi

Diaa A. Marrez, Yousef Y. Sultan.




Abstract

Cyanobacteria are rich sources of bioactive compounds. In the present study, the antifungal activity of different solvent extracts of Microcystis aeruginosa was evaluated. Among these extracts, diethyl ether extract showed the highest antifungal activity against all tested mycotoxigenic fungi ranged from 10.3 and 21.6 mm inhibition zone. Fraction F4 was the best fraction had antifungal activity against all tested fungi. Sub-fraction F4-10 was chosen as the highest sub-fraction had bioactivity. Using TLC bioautography, GC-MS and NMR, two antifungal compounds were isolated, purified and identified as Butylated Hydroxytoluene (BHT) and Hexadecanoic acid, methyl ester.

Key words: Microcystis aeruginosa, Antifungal activity, mycotoxigenic fungi, TLC bioautography






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