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Original Article

PAFMJ. 2016; 66(4): 469-474


EFFECT OF POMEGRANATE PEEL ALONE AND IN COMBINATION WITH ROSIGLITAZONE ON HYPERGLYCEMIA AND DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS

Ayesha Shujaat, Muhammad Mazhar Hussain.

Abstract
Objective: To evaluate the effect of pomegranate peel extract with or without rosiglitazone on plasma glucose and lipid profile in insulin resistant diabetic rats.
Study Design: Randomized controlled trial.
Place and Duration of Study: Department of Physiology, Army Medical College, Rawalpindi, in collaboration with National Institute of Health (N.I.H), Islamabad from 1st January 2011 to 28th May 2011.
Material and Methods: Type 2 diabetes mellitus was induced in sixty healthy rats. The diabetic rats were divided into four groups, namely diabetic control group which received intraperitoneal injection of normal saline daily, pomegranate group which was treated similar to control group and also received pomegranate peel extract (200mg/kg body weight) orally once daily, rosiglitazone group which received intraperitoneal injection of rosiglitazone (5mg/kg body weight) daily and the combined group received both pomegranate extract (100 mg/kg body weight, orally) and intraperitoneal injection of rosiglitazone (2.5 mg/kg body weight) daily for 28 days. After four weeks of treatment, terminal intracardiac sampling was done to measure plasma glucose and lipid profile.
Results: The plasma glucose and mean serum levels of cholesterol, triglyceride, low density lipoproteins and very low density lipoproteins was significantly reduced (p

Key words: Diabetes mellitus, Pomegranate peel extract, Rosiglitazone.



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