Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

Determination of Minimum inhibitory concentrations of Common Biocides to Multidrug-Resistant Gram-negative bacteria

Rajendran Vijayakumar, Mohammad Saleh Al- Aboody, Meshal K. AlFonaisan, Wael Al Turaiki, Suresh Mickymaray, Premanathan Mariappan, Suliman A. Alsagaby, Tim Sandle.

Until now, very few studies have investigated the susceptibility profile of biocides to nosocomial pathogens and none reported in the Saudi Arabia. Hence, the aim of this study was to detect the minimum inhibitory concentrations (MIC) of a range of multidrug resistant (MDR) bacteria: Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae against three common hospital disinfectants: chlorhexidine, benzalkonium chloride and cetrimide.
The in vitro susceptibility tests of the three biocides were studied against 21 MDR A. baumannii, 11 MDR P. aeruginosa and 3 MDR K. pneumoniae strains, isolated from various clinical specimens in the Qassim region, Saudi Arabia. The susceptibility testing was performed by broth microdilution method following Clinical and Laboratory Standards Institute guidelines.
Among 35 isolates tested, there was no reduced susceptibility observed in A. baumannii and K. pneumoniae, however, two isolates of P. aeruginosa were showed reduced susceptibility (> 512 g/mL) against benzalkonium chloride and cetrimide.
Our observations imply that reduced susceptibility was observed with quaternary ammonium compounds against P. aeruginosa and no apparent correlation exists between specific disinfectants and their multidrug resistance character in A. baumannii and K. pneumoniae. Further studies are required to confirm these results in terms of biocides resistance. antalya escort

Key words: Multidrug resistant Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Biocides, Benzalkonium chloride, quaternary ammonium compounds, disinfectant, nosocomial pathogens

Share this Article

Applied Medical Research


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.