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Case Report

PBS. 2016; 6(4): 230-3

Chlorpromazine-induced hyperprolactinemia in a young female and its relation with fibrocystic breast disease

Shazia Farheen Qureshi, Javed Ather Siddiqui, Yousef Bin Ahmed Shawosh.


We report the case of a 20 year old unmarried female patient who has been diagnosed as schizophrenia with intellectual disability. Patient was on chlorpromazine since last three years subsequently develop hyperprolactinemia, later manifested into fibrocystic breast disease. Hyperprolactinemia, is known for decades as neglected side effect of antipsychotic medication. Prolactin is secreted in a pulsatile manner by the anterior pituitary gland. The main physiological function of prolactin is to cause breast enlargement and galactorrhea initially and later develop to fibrocystic breast disease. Routine investigation also revealed hypothyroidism. Prolactin is known as immunomodulator, and has been linked to benign or malignant tumor growth.

Key words: hyperprolactinemia, hypothyroidism, chlorpromazine, fibrocystic breast disease

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