ROS are involved in aging, progressive neuronal death, and age related disorders. During the last decade, there is increasing evidence indicating the beneficial role plant rich phytochemicals for the treatment of oxidative stress-induced disorders in the brain due to their antioxidant activity. Mulberry extract has been reported to have antioxidant activity which attenuates deleterious effects of oxidative stress. Their neuroprotective effects in in vitro and in vivo models of neurodegenerative disorders have been documented. In this paper, mechanisms of action of polyphenols mulberry extracts and related compounds as neuroprotectors in brain damage and aging will be reviewer.
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