Abstract

Sleeping has a critical function to promote health. Studies over the past ten years has documented that sleeping disorders has a strong influence on the risk of infectious diseases and in particular occurrence and progression associated with several major health issues including depression. Recent studies have focused on elucidating the underlying mechanisms that play a role in this situation. This article has been written to review the dynamics of sleep disturbance, sleep restriction, and insomnia on depression and the immune system. Also aimed to discuss the multi-faceted relationship that connect sleep disorder and immunity in terms of the neurobiology of sleep, inflammation and depression. In this context, what is known about the role of sleep on the immune system and the relationship between sleep disorder and depression and the immune system of depression will be reviewed.

Key words: Sleep, depression, immune system, cytokines.