Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and inadequacy of secretion or action of endogenous insulin. Feeding fructose or sucrose can provide model of hyperlipidemia, hyperglycemia and insulin resistance. This research conducted to investigate how CoQ10 can improve the antioxidant defense system and decrease of abnormalities in carbohydrate, protein and lipids metabolism in rat. First group as control rats with i.p. injection of saline daily. Second group fed on normal diet and supplemented by 10% fructose in drinking water ad libitum with i.p. injection of saline daily. Third group as Fructose fed rats treated with coenzyme Q10, 10 mg/kg i.p. daily. After 30 days blood samples were analyzed. Blood serum glucose assay was performed using GOD-POP method. cholesterol and TG review were performed using enzymatic method, HDL using phosphortungstate method, TP using biuret method, albumin using BCG method, insulin and leptin using RIMA method and MDA using TCA method. Using CoQ10 improved carbohydrate, lipid and protein metabolism and decreased oxidative stress. But recuperation did not reach to recorded level in control group.
Key words: Diabetes, Coenzyme Q10, Rat, Biochemical, Antioxidant
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