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Dietary incorporation of whey proteins and galactooligosaccharides exhibits improvement in glucose homeostasis and insulin resistance in high fat diet fed mice

Praveen Kumar Kavadi, Ramesh Pothuraju, Raj Kumar Sharma, Jayasimha Chagalamarri, Gaurav Bhakri, Aswani Mallepogu.


Background: The present study was planned to investigate the effectiveness of whey protein isolate (WPI) of high purity and a galactooligosaccharides (GOS) preparation on glucose homeostasis and insulin resistance under high fat diet (45.47% energy from fat) fed conditions in C57BL/6 mice. The mRNA expression of genes related to gluconeogenesis was also examined. Methods: Fasting blood glucose level, serum insulin & GLP-1 (ELISA) were measured; HOMA-IR determined in different treatment groups. mRNA expression of gluconeogenesis genes in liver and small intestine tissues analysed by qRT-PCR. Results: Dietary incorporation of WPI/GOS alone or in combination was observed to significantly resist (p

Key words: High fat diet, glucose homeostasis, insulin resistance, whey protein isolate, galactooligosaccharides.

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