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Evaluation of protective role of nifedipine on lipid peroxidation using reduced glutathione as model marker

Supratim Ray, Selim Mondal, Nilanta Dana.

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This study was designed with an aim to explore any possible relationship existing between nifedipine-lipid interaction (lipid peroxidation) using reduced glutathione as model marker. Also attempts have been made to explore the effects of various antioxidants like ascorbic acid, butylated hydroxytoluene and naringin on this interaction. The study was performed in vitro using goat liver as lipid source. The study reveals that the nifedipine could significantly arrest the lipid peroxidation process. The results also show that along with antioxidants the antiperoxidative action of nifedipine is enhanced.

Key words: Ascorbic acid; Butylated hydroxytoluene; Naringin; Nifedipine

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