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Original Article

J App Pharm Sci. 2016; 6(10): 170-173


Effect of high intensity interval training on 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine contents in the brain and liver of rats

Ehsan Afroozi-Gerow, Mohammad Esmaiel Afzalpour, Hossein TaheriChadorneshin, Seyed Hosein Abtahi-Eivary.

Abstract
Production of reactive oxygen species yields serious damage oxidation of proteins, lipids and genomic structures. Studies have shown that production of reactive oxygen species increases during intensive exercise training. This study aimed to investigate the effect of high intensity interval training on 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine levels in the brain and liver of rats. 16 adult Albino Wistar rats were randomly divided into sedentary control and high intensity interval training groups. Animals ran on treadmill for 6 weeks, 6 days per week, at 95 to 100 percent of maximal oxygen consumption. Using commercial kits, the content of 8-oxoguanine DNA glycosylase and 8-hydroxy-2'-deoxyguanosine were measured using sandwich ELISA assay. Data analyzed using Studentís T-test at p

Key words: High intensity interval training, 8-oxoguanine DNA glycosylase, 8-hydroxy-2'-deoxyguanosine, Liver, Brain



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