OBJECTIVE: To detect the prevalence of physical co-morbidities according to International
Classification of Diseases(ICD-10) among patients with Depressive disorder.
DESIGN: Descriptive cross sectional study.
SETTING: Psychiatric consultation clinic of JPMC Karachi.
METHODS: Patients of either gender and age >18 years were consecutively selected after informed
consent, Ethical issues were addressed according to Institutional Review Board (IRB),
JPMC, Karachi. Patients with psychotic symptoms, personality disorders, dementia, and history
of substance use were excluded. ICD-10 criteria, beside complete history, physical examination
& lab investigations were used to confirm the diagnosis of depression and physical co-morbid.
Prescribed questionnaire was used to collect the data and analyzed in SPSS version-17. Descriptive
statistics were calculated for age, gender, marital status, education, socioeconomic
status and co-morbidity.
RESULTS: Total 100 cases fulfilled the inclusion criteria. Their Mean ±SD age was 32.7 ±16.7
years. Both genders were equally vulnerable, (50% each). Fifty three percent had moderate, 31%
mild and 16% had severe depressive disorder. Hypertension was the most common (18%) in
male patients & sinusitis was the most common (28%) in female patients with depression. Other
co-morbidities included Diabetes Mellitus, Epilepsy, Migraine, HCV, Anemia, Chronic Kidney
Disease (CKD), Urinary Tract Infection (UTI) & Menopausal syndrome (in women), Obesity,
Asthma and Facial pain.
CONCLUSION: Physical co-morbidities are prevalent among patients with depressive disorder.
Presence of physical co-morbid may decreases the chances of treatment compliance, increases
risk of treatment failure, relapse of depression, worse prognosis and elevated the treatment
cost. Early detection and simultaneous management of these co-morbid with depression are
Key words: Depression, Physical comorbidities, Hypertension, Sinusitis