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Original Article

J Liaquat Uni Med Health Sci. 2016; 15(2): 78-82


Malondialdehyde, Blood Lipids and Antioxidant Activity in Newly Diagnosed Type 2 Diabetics

Mona Humaira, Abdul Raqeeb, Azhar Memon, Haji Khan Khoharo.

Abstract
OBJECTIVE: To determine malondialdehyde, blood lipids and anti oxidants in newly diagnosed
type 2 diabetic patients.
STUDY DESIGN: Observational, comparative study
PLACE & DURATION: Department of Medicine, Liaquat University of Medical and Health Sciences
Hospital from February 2013- May 2014.
SUBJECTS & METHODS: 97 newly diagnosed type 2 diabetics and 50 healthy controls were selected
through non-probability purposive sampling according to inclusion and exclusion criteria.
Blood samples were collected after 8-12 hours of fasting. Fasting blood glucose level, lipid
and lipoprotein levels were measured by Cobas e411 analyzer. Malondialdehyde (MDA), Superoxide
dismutase (SOD) and Glutathione peroxidase (GPX) were measured by Diagnostics kit.
Zinc and ascorbic acid were measured by using Centronic GmbH-Germany Kit. Albumin,
bilirubin, and uric acid were measured on Hitachi Chemistry analyzer. Data was analyzed on
SPSS version 21.0. The significant p-value was taken at ≤ 0.05.
RESULTS: MDA, blood lipids and anti oxidant mechanisms showed significant differences between
diabetics and healthy controls. Total blood lipids and lipid sub fractions were elevated in
diabetics compared to controls. MDA was raised 5.16±0.91 vs. 2.16±0.62 μmol/l in diabetics and
controls respectively (p=0.0001). The SOD, GPX, Ascorbic acid, Zinc, albumin, uric acid and
bilirubin were reduced in diabetics (p

Key words: Malondialdehyde, Anti oxidants, Diabetes mellitus.



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