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Original Article

J App Pharm Sci. 2016; 6(12): 061-066


GC-MS analysis of bioactive constituents of Aristolochia bracteolata Linn with in-vitro antioxidant properties

Trayee Sarkar Das, Latha Ramesh, Paul Agastian.

Abstract
The aim of this study was to evaluate the antioxidant activity of hexane, ethyl acetate and methanol extracts of Aristolochia bracteolata Linn. Methanol extract showed increased scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC50 270.12 1.12 g/ml), hydroxyl (IC50 450.04 0.71 g/ml), nitric oxide (IC50 640.06 1.24 g/ml) and hydrogen peroxide (IC50 300.51 0.67 g/ml) radicals, as well as high reducing power. Methanol extract also showed strong suppressive effect on lipid peroxidation (IC50 400.011.23) and metal chelating ability of methanol extract showed moderate effect (IC50 680.090.33) when compared to the reference standard. The results obtained in the present study clearly indicate that methanol extract has a significant potential to use it as an antioxidant agent. In the present study the methanol extract ofAristolochia bracteolata has been subjected to GC-MS (Gas Chromatography-Mass Spectrometery) analysis. Sixty chemical constituents have been identified, The major peaks fromGC-MS results revealed the presence of seven different phytochemical constituents likedodecane (7.50%), tetradecane (7.31%), tridecane (6.59%), undecane (6.29%), pentadecane (3.99%), hexadecane (2.69%) and decane (1.49%) whereas some other minor peaks corresponds to the presence of other phytoconstituents.

Key words: Antioxidant, Aristolochia bracteolata, GC-MS, Phytoconstituents



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