Abstract

Objective: To examine the association between transfusion frequency, serum ferritin levels, and splenomegaly in β-thalassemia major (β-TM) patients.
Methodology: A cross-sectional study of 194 β-TM patients (0–18 years) was conducted at thalassemia center in Hyderabad, Pakistan. Data on demographics, transfusion frequency, serum ferritin, and chelation adherence were collected. Splenomegaly was assessed clinically and via ultrasonography. Pearson’s correlation and chi-square tests were applied, with p ≤ 0.05 considered significant.
Results: Splenomegaly was present in 61.34% of patients. Significant correlations were found between spleen size and transfusion frequency (r = 0.62, p

Key words: Thalassemia, splenomegaly, ferritin, iron overload.