Abstract

Objectives: Diarrhoeal disease is often a leading source of mortality and morbidity, especially among children in developing countries causing a major healthcare problem. As per suggestion of WHO, treatment of diarrhoea with traditional medicine is the main focus of our present studies. The present study is designed to evaluate the anti-diarrhoeal activity of crude methanol extract of Urena sinuata L. (U. sinuata) and its fractions.
Methods: Crude methanol extracts are obtained by in vacue methods and its fractionating is done by Kupchan partitioning method. The anti-diarrhoeal activity is screened by castor oil-induced diarrhoea, castor oil-induced enteropooling and gastrointestinal motility test.
Results: The diarrheal severity was reduced significantly (P

Key words: Anti-diarrheal activity; Urena sinuata L.; Castor oil; Enteropooling; Intestinal transit; Solvent-solvent partitioning