Home|Journals|Articles by Year|Audio Abstracts
 

Original Article

J App Pharm Sci. 2016; 6(11): 105-113


Sub-chronic oral toxicity study of Kushta Hajrul-Yahood (A Herbo-mineral Unani formulation) in Wistar rats

Showkat A. Dar, Seema Akbar, Khalid Ghazanfar, Mariya Hamdani, Tazeen Nazir, Masood S. Mir, Akbar Masood, Humma Rafiq, Showkat A. Ganie.




Abstract

PD (Kushta Hajrul Yahood) is a Unani drug used for the treatment of renal and bladder calculi. The aim of the study was to demonstrate the scientific validity of detoxification method for preparation of Kushta and also to investigate the sub-chronic oral toxicity study of PD and CM (Crude material of Kushta Hajrul Yahood-its Un-detoxified form) in Wistar rats. Animals were orally treated once daily with test substance at the dose level of 1000mg and its two sub fractions 500 and 250mg/kg body weight for 90-days. Rats were observed throughout the study period. Body weight, feed and water consumption were recorded weekly. Overnight fasted rats were sacrificed on 91st day. Blood sample were collected for Haematological and biochemical studies. Organs were collected to record the organ weight and tissues for histology. The results showed elevation of liver enzymes due to the administration of PD at the dose level of 1000mg/kg body weight only, while-as in case of CM, there were significant elevation of liver enzymes at all the three doses. This elevation of enzymes also correlates with histopathological changes in liver tissues. This study concludes that the method of detoxification adopted for preparing Kushta substantially reduces the elements of toxicity.

Key words: Keywords: Sub-chronic toxicity, Hajrul-Yahood, biochemical parameters, haematological parameters, Histopathology.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.