Acute interstitial nephritis is characterized by inflammatory infiltration and edema in renal insterstitium and is associated with acute failure in renal functions. The most frequent cause of AIN is drug use which is responsible approximately 60-70% of AIN cases and antibiotics are the leading among almost all kinds of medication classes. Hypersensitiviy reactions to a certain drug or any metabolites of a drug play a major role in AIN pathogenesis. Regardless from etiologic factor, most of AIN patients refer to hospital with non-specific symptoms (nausea, vomiting, fatique etc.) or acute failure findings of renal functions. Renal biopsy is the gold standard in diagnosis of AIN, revealing classical pathologic sign of inflammatory infiltration in renal interstitium. When diagnosis of AIN is certain, suspected drug must be discontinued instantly and oral or intravenous steroid therapy must be started immediately. Steroid therapy has a positive correlation with rapid and complete remission, but total recovery may not be achieved in all cases. In this review, we tried to look over this illness which needs more attention in clinical practice.
Acute interstitial nephritis, drug-induced, acute renal failure
Article Language: Turkish English