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Comet assay application in evaluation the safe use of medicinal plants

Ana Mariel Mohamed, María Alejandra Cangiano, Lucía Esther Alcaráz, Sara Elena Satorres, Analía Liliana Laciar, Claudia Maricel Mattana.


Genotoxicity of three aqueous extracts obtained of Acacia caven (espinillo), Acacia furcatispina (garabato) and Prosopis torquata (tintitaco), was evaluated by comet assay. Three concentrations (0.1; 10 and 20 mg/mL to A. cavens and A. furcatispina; 0.2; 2 and 20 mg/mL to P. torquata) were tested and the damage index for each was calculated. Based on the results, it was determined that both aqueous extracts of A. cavens and A. furcatispina showed no damage DNA at 0.1 and 10 mg/mL but, at 20 mg/mL induced significant differences DNA primary damage in human blood peripheral cells (p< 0.05), showing moderate level damage (category 2). On the other hand, P. torquata extract was strongly genotoxic at all concentrations tested.

Key words: Key words: Acacia cavens, Acacia furcatispina, Comet Assay, Genotoxicity, Prosopis torquata

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