Abstract

The Aspergillus genus is one of the most widespread fungal genera with significant pharmaceutical, industrial, and agricultural importance. Aspergillus ochraceopetaliformis, a member of this genius, is known for producing a diverse class of bioactive metabolites. These metabolites include pyran derivatives, cyclopentenones, lactones, anthraquinones, polyketides, sesquiterpenoids, alkaloids, biphenyl ethers, isocoumarins, cyclopeptides, and other secondary metabolites with distinct biological activities. Despite the potential of this fungus, there is lacking comprehensive review of its metabolites, biosynthesis pathway, and biological properties. The aim of this work is to provide a thorough overview of chemical diversity, biological activities, and biosynthetic pathways of the reported metabolites from A. ochraceopetaliformis in the period from 2016 to November 2024. The reported results highlight the untapped potential of A. ochraceopetaliformis metabolites that could encourage further research into their mechanisms of action and therapeutic uses in developing novel drug leads for various disorders.

Key words: Filamentous fungi, Aspergillus ochraceopetaliformis; life on land; microbial bioactive metabolites; biological activities polyketides; alkaloids; fungal biosynthesis; drug discovery