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Original Research

Serum magnesium levels in type 2 diabetes with metabolic syndrome

K. C. Razeena, Jean Maliekkal, Geetha Nair.


Background: Diabetes is a serious illness with multiple complications and premature mortality. Type 2 diabetes is the predominant form of diabetes worldwide, and it accounts for 90% of cases globally. Large majority with Type 2 diabetes have the metabolic syndrome (MS). MS is a widely prevalent disorder, and it is associated with increased risk for the development of cardiovascular disease, cerebrovascular disease, and renal disease.

Aims and Objectives: The present study was conducted to find out the relationship between serum magnesium levels and MS.

Materials and Methods: The study was conducted in 135 diabetic patients. They were divided into 2 groups. 90 Type 2 diabetic patients with MS and 45 Type 2 diabetic patients without MS. 45 normal healthy adults were included in the control group.

Results: The study showed that mean serum magnesium levels were significantly lower in patients with MS when compared with that of healthy adults. Correlation analysis revealed a significant negative correlation between serum magnesium levels and fasting blood sugar, systolic blood pressure (BP), diastolic BP, triglyceride levels, and a positive correlation between serum magnesium and high-density lipoprotein levels.

Conclusion: MS is highly prevalent in our population. Low serum magnesium levels play an important role in the pathogenesis of MS. Studies have shown that magnesium intake is inversely associated with incident MS and its components. Hence, magnesium supplementation in young adults can prevent the development of MS and thereby the complications related to it.

Key words: Magnesium; Metabolic Syndrome; Type 2 Diabetes

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