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Sedative Effects of the Combination of Detomidine and Midazolam In HorsesErika ribeiro gomes, larissa alexsandra felix, lucas wamser fonseca gonzaga, naira fernanda dias da silva, bruna christina fernandes soares soares, joão vitor fernandes cotrim fernandes cotrim de almeida, gabriela pereira souza, rodrigo norberto pereira, marilda onghero taffarel, marcos ferrante. Abstract |  Download PDF | Cited by 0 Articles |  Post | Background: The combination of detomidine and midazolam may provide safer sedation with muscle-relaxant effects, which is particularly necessary during standing procedures.
Aim: Thus, the objective of this study was to evaluate the sedative and muscle-relaxant effects of the detomidine-midazolam combination in horses through a pharmacodynamic study.
Methods: Five horses were used and subjected to four experimental protocols: 15 µg/kg of detomidine (D15); a combination of detomidine (15 µg/kg) with 25 µg/kg (DM25), 50 µg/kg (DM50), or 75 µg/kg (DM75) of midazolam, administered intravenously. Sedative and muscle-relaxant effects, as well as physiological parameters, were evaluated and statistically analyzed.
Results: All protocols resulted in a decrease in head height, although no significant difference was observed among them. Acoustic stimulus response and tongue tone relaxation showed significant effects in the global analysis.
Conclusion: This study contributes to the understanding and application of this combination in equine sedation protocols.
Key words: sedation, α-2 agonists, benzodiazepines, chemical restraint
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