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Original Article

Med Arch. 2020; 74(5): 332-336

Mesenchymal Stem Cell-injected Omental Patch More Effective Promoting Wound Healing in Bowel Perforation Animal Model

Vito Mahendra Ekasaputra, Agung Putra, Adi Muradi Muhar, Jherin Varessa, Rafeni Bunga Cikita, Satya A.P. Wijaya, Mohammad Ariq Nazar.

Introduction: Bowel perforation (BP) occurs as the complication of many gastrointestinal problems. Omental patch (OP) is one of the methods to place omentum flaps in the perforated area. Mesenchymal stem cells (MSCs) may increase regeneration process in all tissues.
Aim: to demonstrate the role of MSC in accelerating of wound healing process by analyzing fibroblast and collagen appereance in perforated bowel conditions. Methods: Using a BP rabbit model, 18 rabbit were randomly assigned into three groups: combination of umbilical cord (UC)-MSCs injection and OP (T1), OP only (T2) and vehicle control (Veh). Hematoxylin-eosin staining and Massonís trichrome staining were performed to analyze the level of fibroblast and collagen. Wound length were measured using standarized caliper. Results: The study showed a significant (P

Key words: Mesenchymal stem cells, fibroblast, collagen, wound length, Bowel perforation

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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.