This study investigated the blood biochemistry responses of cockerels experimentally infected with a velogenic Newcastle disease virus (NDV) strain, KUDU 113. One hundred Isa white cockerels were used for the study. The cockerels were obtained at day-old and randomly divided into groups A- vaccinated and infected, B - unvaccinated and infected and C- unvaccinated and uninfected (control) consisting of 30, 30 and 40 birds respectively. Group A was vaccinated against NDV with La Sota vaccine at three weeks of age while Groups B and C were not vaccinated. After six weeks, each bird in groups A and B were inoculated intramuscularly (im) with the velogenic NDV while the control group was not inoculated. Blood samples were randomly collected through the jugular vein from five birds in each group, allowed to clot at room temperature, centrifuged and serum harvested. Blood biochemistry determinations were carried out on days 0, 3, 6, 9, 12, 15 and 21 post-inoculation (pi). Parameters determined included serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activities, total serum proteins, albumin, globulin, total bilirubin, blood glucose level, total cholesterol, total calcium, blood urea nitrogen and uric acid. Data generated were analyzed using ANOVA and Students t-test. Results showed decreased (p
Key words: Chickens, Isa white, Velogenic NDV, KUDU 113, Blood biochemistry
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