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Qualitative and quantitative changes of corneal endothelial cells and central corneal thickness in pseudoexfoliation syndrome and pseudoexfoliation glaucoma

Saroj Sarowa, Jaishri Murli Manoher, Kalpana Jain, Yamini Singhal, Deepak Devathia.


Background: Pseudoexfoliation syndrome (PXS) is age-related systemic microfibrillopathy, caused by gradual deposition of extracellular grey and white material over various tissues. PXS is frequently associated with secondary open angle glaucoma. In Pseudoexfoliation eyes, corneal endothelial changes have been reported. The present study analysed corneal endothelial morphometry and central corneal thickness in PXS and pseudoexfoliation glaucoma.

Objective: To evaluate qualitative and quantitative changes of corneal endothelial cells and central corneal thickness in pseudoexfoliative(PEX) eyes with and without glaucoma and to compare with normal eyes and eyes with primary open-angle glaucoma(POAG).

Materials and Methods: A total of 80 patients were included in this study: 20 eyes with PXS, 20 eyes with pseudoexfoliation glaucoma(PXG), 20 eyes with POAG, and 20 normal eyes. Corneal endothelial cell density(ECD), coefficient of variation(CV) in cell size, percentage of hexagonal cells and central corneal thickness were measured using a non-contact specular microscope.

Results: ECD (p-value

Key words: Corneal endothelium, Central corneal thickness, Pseudoexfoliation Glaucoma Pseudoexfoliation Syndrome, Specular Microscopy

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