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Original Research

SETB. 2016; 50(4): 309-14

Should children diagnosed with cerebral calcification be screened for celiac disease?

Sedat Işıkay, Serkan Kırık, Nurgül Işıkay, Şamil Hızlı, Olcay Güngör, Yasemin Kırık.

Objective: In this study, we aimed to examine the prevalence and relationship of celiac disease (CD) in children with cerebral calcifications (CC).
Material and Methods: Children with cerebral calcifications were screened for celiac disease using the anti-tissue transglutaminase IgA antibody.
Results: A total of 129 children with CC (75 boys, 54 girls; age: 6 months to 16 years) were evaluated. Control group consisted of 223 healthy children. The prevalence of CD was significantly higher in patients with CC than control subjects (p=0.01). In three patients pathological examination of duodenal biopsy resulted as total villous atrophy. All three patients had both iron deficiency anemia and short stature problem. Although, no calcification in occipital lobe was detected in computed tomography of these three patients, there were nonspecific calcifications in choroid plexus and pineal gland localizations.
Conclusion: According to results from our study, prevalence of celiac disease being low in patients with intracerebral calcifications suggested that there is not a strong correlation between development of calcification and celiac disease. It suggested that occurrence of calcification in choroid plexus and/or pineal gland might be related to celiac disease.

Key words: Celiac disease, cerebral calcification, child

Article Language: Turkish English

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Journal of Molecular Pathophysiology


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