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Original Article

J App Pharm Sci. 2016; 6(10): 029-036


Mechanism of Relaxant Action of Ethyl 6-amino-5-cyano-2-methyl-4-(pyridin-4-yl)-4H-pyran-3-carboxylate Mainly Through Calcium Channel Blockade in Isolated Rat Trachea

Soledad Alemán-Pantitlán, César Millán-Pacheco, Miguel A. Vázquez, Fernando Hernández-Borja, Rafael Villalobos-Molina, Blanca Bazán-Perkins, Samuel Estrada-Soto.



Abstract
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This study aims to investigate the mechanism of relaxant action of Ethyl 6-amino-5-cyano-2-methyl-4-(pyridin-4-yl)-4H-pyran-3-carboxylate (1) in in silico study and ex vivo tracheal rat rings pre-contracted with carbachol (1 µM). Compound 1 was more active than theophylline a phosphodiesterases (PDE’s) inhibitor used as positive control. Moreover, pretreatment with 1 significantly shifted to the right the carbachol-induced contraction and did not allow to reach the maximum effect (p

Key words: Calcium channel blockade; docking studies; Ethyl 6-amino-5-cyano-2-methyl-4-(pyridin-4-yl)-4H-pyran-3-carboxylate; relaxant effect; tracheal relaxation

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010203040506070809101112
2025

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