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Toxicological study on aqueous extract of Allanblackia froribunda (Clusiaceae) on rats

Dieudonné Massoma Lembè, Marie Ngaha Njila, Emma Bend, Judith Domkam, Pierre Claver Oundoum Oundoum, Fabrice Dongho Dogmo, Gustavo F Gonzales.


Aim: The acute and sub-acute toxic effects of aqueous extract of Allanblackia froribunda (Clusiaceae) were studied in rats.
Methods: The acute toxicity was carried out orally with 0, 14, 16, 18 and 20 g kg-1 b/w and intraperitoneally with 0, 50, 100, 150, 200 mg kg-1 body weight, while the subacute was only carried out orally with 0(distilled water), 400, 500 and 600 mg kg-1 b/w for four weeks.
Results: In acute test, the oral administration did not cause any death treatment related signs. The LD50 estimated to be 125 mg kg-1 (Intraperitoneal route). We noted a decrease in food, water consumption and body weight of treated animals. Diarrhea occurred in rats at dose 150 mg kg-1. Analysis of serum showed an increase in ALT at dose 50 mg kg-1 (p

Key words: Allanblackia floribunda, acute and subacute toxicity, oral and intraperitoneal administration, animal toxicology

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