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Correlation between serum uric acid, nitric oxide, ferrtin and HbA1c levels in type II diabetic patients



Objectives: To estimate fasting plasma glucose (FPG), serum ferritin, HbA1c, uric acid and serum nitric oxide levels in type 2 diabetes mellitus (T2DM) subjects and compare the parameters with healthy controls and also to assess the correlation analysis between the biochemical parameters in T2DM patients.

Materials and Methods: A case control study is conducted with a total of 56 diagnosed T2DM subjects and 31 healthy controls. FPG, serum ferritin, HbA1c, uric acid and serum nitric oxide levels were measured in all individuals.

Results: The mean levels (mean  SD) of FPG, serum ferritin, HbA1c, serum uric acid and serum nitric oxide in control group were 98.06±7.28, 84.6±36.8, 5.46±0.84, 4.72±1.41 and 39.0±4.7 respectively. Similarly, in T2DM patients mean levels of 179.5±53.2, 457.9±402.2, 9.49±1.90, 8.57±2.38 and 100.9±26.5 were obtained for respective parameters. In T2DM subjects, mean values of serum ferritin, HbA1c, uric acid and serum nitric oxide were found to be significantly increased (p

Key words: Oxidative stress, diabetes mellitus, iron over load, serum ferritin, serum uric acid.

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