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Original Article

J Liaquat Uni Med Health Sci. 2016; 15(1): 16-20

Vitamin D3 in Newly Diagnosed Pulmonary Tuberculosis Patients: A Comparative Case Control Study

Azhar Memon, Abdul Raqeeb, Mona Humaira, Haji Khan Khoharo.

OBJECTIVE: To evaluate Vitamin D in Pulmonary tuberculosis and normal healthy adults.
STUDY DESIGN: Case control study.
PLACE AND DURATION: Department of Medicine, Isra University Hospital Hyderabad, from
January 2013- June 2014.
SUBJECTS & METHODS: A sample of 209 diagnosed pulmonary tuberculosis patients was selected
through non-probability purposive sampling according to inclusion and exclusion criteria.
After taking informed written consent from the participants, Vitamin D was measured by ARCHITECT
I 1000 system for estimation of 25-OH- D3. . The data was recorded on a pre-structured
proforma, and analyzed on SPSS version 21.0. The significant p-value was taken at ≤ 0.05.
RESULTS: The mean S.D serum level of 25-hydroxyvitamin D3 in cases and controls were
27.19.7 and 36.88.1 (ngdl-1) respectively (p=0.0001).The 25-hydroxyvitamin D3 levels as low as
6 ng/dl were observed in pulmonary tuberculosis subjects. The normal, insufficiency and deficiency
of 25-hydroxyvitamin D3 were observed in 37(33%), 16 (14.2%) and 59 (52.6%) in cases
respectively compared to controls as 57 (58.7%), 21(21.6%) and 19 (19.5%) respectively.
CONCLUSION: Patients with pulmonary tuberculosis are significantly Vitamin D deficient. Vitamin
D supplements may be prescribed, however further studies are warranted.

Key words: Vitamin D3, Pulmonary tuberculosis, Sindh.

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