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J Liaquat Uni Med Health Sci. 2016; 15(1): 12-15

Comparative Study of Clinical Profile in Patients with Solitary versus Multiple Gall Stone

Jai Kumar Misrani, Sadaf Iqbal, Nazir Ahmed Sasoli, Zulfiqar Ali Memon, Sohail Ahmed Ahmedani.


BACKGROUND: Gallstones represent a major health problem across the world.1 In the United
States the prevalence is about 10% and increasing up to 30% in advance age people.2 Its Prevalence
in Islamic Republic Pakistan is around 15 to 20 %.3
OBJECTIVE: Aim of our study is to assess the differences in clinical presentation between single
and multiple gallstones.
DESIGN: Comparative study.
SETTING: This study was conducted at surgical department of Liaquat University Hospital Jamshoro,
Sindh, Pakistan.
DURATION: 1st Feb 2010 to 31st January 2014.
SAMPLE SIZE: Total one hundred patients.
METHODOLOGY: All sonographically diagnosed patients of gallstones admitted into the ward.
Clinical presentation like signs, symptoms and preoperative ultrasound findings of all patients
were noted on predesigned performa, than after all necessary preoperative workup patients fit
for surgery underwent cholecystectomy under elective conditions. The gallbladder was incised
and the gallstones were exposed. The number of stones (single or multiple) in each gallbladder
was recorded and on this basis all patients were divided into two groups. Group “A” labeled as
a single stone and group “B” multiple stone.
RESULTS: The age range from 20 to 70 years, mean age was 44±5.5 years. Incidence of disease
is about five times higher in female than males (80% female, 20% male). 80% of patients had
multiple stones, 20% patients had single stones. Majority of patients of group “A” has colicky
type of pain and located in right upper quadrant and majority of group “B” patients has dull
pain and located in Epigastrium. Other clinical symptoms like dyspepsia, vomiting and fever
have no major difference in both groups. Sonographic findings are also almost same in both
CONCLUSION: It is concluded from our study that the clinical and Sonographic presentation is
almost same in both groups, except site and type of pain.

Key words: Gall stones, clinical presentation, solitary, multiple.

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