Background: The studies have reported that high serum uric acid (UA) and low nitric oxide (NO) levels are strongly associated with prevalent health conditions such as obesity, insulin resistance, metabolic syndrome, diabetes, essential hypertension, and renal disease. None of the studies have examined the predictive value of serum UA and NO in the diagnosis of Type 2 diabetes, especially from India.
Aims and Objectives: To find out the predictive value of serum UA and NO in the diagnosis of Type 2 diabetes.
Materials and Methods: This was a casecontrol study. A total of 40 cases of Type 2 diabetes were included (20 male and 20 female). Age- and sex-matched apparently healthy subjects (n = 40) without any history or symptoms of diabetes and other metabolic disorders were chosen as the control (20 male and 20 female).
Results: The serum UA was significantly (P = 0.0001) higher among the cases (16.23 ± 2.89) compared to controls (11.77 ± 5.92). However, NO was found to be significantly lower among the cases (47.33 ± 10.70) than controls (61.19 ± 10.48). The sensitivity and specificity of serum UA were 62.5% and 57.5%, respectively, with a cutoff value of 15.75. A moderate area under the curve (AUC) was found which was statistically significant. A reasonable sensitivity (70%) and specificity (77.5%) of NO were also observed, however, AUC was small.
Conclusion: We found moderate sensitivity and specificity of serum UA and NO in the diagnosis of Type 2 diabetes.
Key words: Type 2 Diabetes; Serum Uric Acid; Serum Nitric Oxide; Sensitivity; Specificity
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