Background: Nowadays PPI present cornerstone in the medical therapy of bleeding peptic ulcer. Controlled pantoprazole data in peptic ulcer bleeding are few. Aim: To compare the effect of intravenous (iv) pantoprazole (PPI) with iv ranitidine (H2RA) for bleeding peptic ulcers after endoscopic therapy. Methods: After endoscopic haemostasis, 122 patients were randomized to PPI 80 mg + 8mg/h or H2RA 50 mg + 13mg/h, both for 72 h and to continue with oral equivalent dose of these medicaments. Patients underwent second-look endoscopy on day 3 or earlier, if clinically indicated. The primary endpoint measure was re-bleeding before discharge and 0.05), the need for surgical intervention 5.00 vs. 6.45% (3 vs. 4 patients and P= 1.00 ) and the mortality rate 1.66 vs. 3.22% (1 vs. 2 patients and P> 0.05).Conclusion: A high-dose pantoprazole infusion is more effective than a ranitidine infusion for prevention of re-bleeding after endoscopic epinephrine injection in patients with peptic ulcers and active bleeding or non-bleeding visible vessels (P
Key words: Helicobacter pylori, bleeding peptic ulcer, endoscopic hemostasis.
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