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Study of variations in lipid profile in different trimesters of pregnancy

Manish Kumar Mishra, Rina Sharma, Deependra Sharma, Avanish Mishra, Diwaker Sharma.


Background: This study has been conducted to show a correlation of rise in lipid profile in all three trimesters when compared with nonpregnant controls.

Objectives: As previous studies showed that increased lipid profile during pregnancy may lead to serious complications in both mother and fetus. Hence, the aim of our study is to monitor the lipid profile values during all the three trimesters of pregnancy and prevent the complications in both mother and fetus.

Materials and Methods: A total 180 pregnant patients were taken with 60 in each trimester. 60 healthy nonpregnant women were taken as control subjects. In both study and control groups, we estimated lipid profile which includes total cholesterol (TC), serum triglycerides (TGs), high-density lipoprotein (HDL), and low-density lipoprotein (LDL).

Results: In comparison between study and control groups, the levels of TC, serum TGs, and HDL were significantly high in all the three trimesters, but the levels of LDL were significantly high in the second and third trimesters only.

Conclusion: Deranged lipid metabolism in pregnancy is associated with complications in mother and fetus. Therefore, it is recommended to get lipid profile done as a routine investigation in all the three trimesters of pregnancy to avoid maternal and fetal morbidity and mortality.

Key words: Lipid Profile; Trimesters; Pregnancy; Feto-maternal

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