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Case Report

Open Vet J. 2019; 9(1): 81-87

Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy

Massimo Giangaspero,Lorenzo Domenis,Serena Robetto,Riccardo Orusa.

Cited by 1 Articles

In 2015, a young female Alpine chamois (Rupicapra rupicapra rupicapra), originated from the Aosta Valley Region, Northernwestern Italy, was conferred to the National Reference Center for Wild Animal Diseases for pathologic examinations. Histological analysis revealed a severe meningoencephalitis characterized by lymphocytic and plasmacellular infiltration, gliosis, perivascular cuffs and leptomeningitis at the level of brain and brain stem. Laboratory investigations included polymerase chain reaction, sequencing and characterization by phylogenetic analysis and evaluation of the internal ribosome entry site (IRES) secondary structure in the 5’ untranslated region. These tests identified the pathological agent as Border Disease virus (BDV), a known health risk in domestic small ruminants. Genetic characteristics of the isolated strains, closely related to ovine and caprine strain sequences from neighbouring regions of Piedmont, France and Switzerland, suggested geographic segregation and micro-evolutive steps within the species.

Key words: Alpine chamois, Border Disease virus, Meningoencephalitis, Pestivirus, Rupicapra rupicapra rupicapra.

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