Home|Journals|Articles by Year|Audio Abstracts

Original Article

J App Pharm Sci. 2017; 7(8): 123-130

Effect of Poikilacanthus glandulosus (Nees) Ariza branches and gallic acid against viability of Echinococcus ortleppi protoscoleces

Thiele Faccim de Brum, Roberta da Silva Jesus, Bianca Vargas Belke, Danieli Urach Monteiro, Natalia Jank Mossmann, Mariana Piana, Sílvio Terra Stefanello, Félix Alexandre Antunes Soares.


The aim of this study was to assess the antioxidant capacity and to evaluate effect of P. glandulosus on the viability of protoscoleces of Echinococcus spp. as well as determine the possible substance in charge for this action. Echinococcus ortleppi protoscoleces were exposed front of the crude extract and butanol fraction and gallic acid at different times. Phytochemical study revealed the presence of triterpenoids, steroids, coumarins, catechins, phenols, anthocyanins, anthocyanidins and cardioactive heterosides. The highest polyphenol and flavonoids content was found in the ethyl acetate (151.34±1.71 mg/g) and dichlorometane (123.30±1.46 mg/g), respectively. For assays with DPPH the ethyl acetate fraction was highlighted (IC50 95.48±0.35 µg/mL) and the dichlorometane fraction significantly reduced lipid peroxidation (IC50 135.75±2.39 µg/mL) and also the oxidation of DCFH (15.6 µg/mL). The crude extract, butanol fraction and gallic acid showed scolicidal action of 100% at 15, 10 and 15 minutes, respectively.

Key words: Acanthaceae; antioxidant; gallic acid; protoscoleces; scolicidal agent.

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.