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Original Article

PAFMJ. 2016; 66(2): 216-220


DETECTION OF STAT-1 IN PATIENTS CO-INFECTED WITH HEPATITIS B AND C RESISTANT TO INTERFERON

Naveeda Manzoor, Amir Rashid, Suhail Razak, Asifa Majeed.

Abstract
Objective: Current study was designed to determine the STAT-1 in co-infected patients of hepatitis B and C resistant to interferon therapy.
Study Design: Cross-sectional analytical study.
Place and Duration of Study: Department of Biochemistry & Molecular Biology & Gastroenterology departments of various hospitals of Rawalpindi.
Material and Methods: The study included 15 co-infected patients of hepatitis B and C resistant to interferon therapy and 15 healthy individuals as control.
Methodology: Detection of STAT-1 was done by conventional PCR technique.
Results: Sixty seven percent of the patients were expressing STAT-1 in their blood while 33% of the patients did not have STAT-1. Controls showed 57% detection of STAT-1 and 43% did not exhibit STAT-1. Mean age of the patients and controls was 35.90 ± 8.95.Comparison between patients and controls was done by chi square test. Fisher exact probability value obtained was 0.287 which was not significant.
Conclusion: Patients suffering from hepatitis B and C co-infection resistant to interferon therapy revealed higher detection of STAT-1 which indicate greater liver damage, fibrosis and an extensive and severer disease course in co-infection

Key words: Co-infection, HBV, HCV, Interferon, STAT-1.


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