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Original Article

PAFMJ. 2015; 65(0): S178-S182


Khizar Ishtiaque Khan, Imran Ashraf, Muhammad Akmal, Ahmed Waqas, Shahid Mahmood, Shahzad Ahmed Qasmi, Faran Kiani.

Objective: To evaluate the efficacy of 0.2% glyceryl trinitrate (GTN) paste as first line treatment in acute anal fissure with no severe side effects.
Study Design: Randomized control trial.
Place and Duration of Study: Combined Military Hospital Kharian and Combined Military Hospital Malir Pakistan from January 2008 to August 2010.
Patients and Methods: Patients presenting with acute anal fissure were randomized in 2 groups by using computer generated table. Group A received 0.2% GTN paste and group B received lignocaine gel twice daily in addition to high fiber diet, sitz bath and stool softeners. Pain scores on 100 mm Visual Analogue Scale, healing of fissure and side effects (headache and flatus incontinence) were noted at 0,2,4,6 and 8 weeks. Evolution to chronic anal fissure and recurrence rates (3 and 6 months) was also noted. Data was entered on SPSS 16.0 and p value was calculated.
Results: Out of 161 patients, 109 patients (56 in group A and 53 in group B) completed the study. Demographical data was comparable in both the groups. Results were statistically significant (p 0.05). Patients experiencing mild and moderate headache were 5 and 3 respectively whereas 10 (17.8%) patients had temporary flatus incontinence in group A.
Conclusion: Use of 0.2% GTN as first line treatment in acute anal fissure showed better pain relief fastened healing, less recurrence rates and also prevents its evolution to chronicity

Key words: Acute anal fissure, Chronicity, GTN.

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Journal of Molecular Pathophysiology


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