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Original Article

PAFMJ. 2016; 66(0): S41-S45


TREATMENT OF ACUTE MOUNTAIN SICKNESS: IS THE COMBINATION OF ACETAZOLAMIDE AND DEXAMETHASONE BETTER THAN ACETAZOLAMIDE ALONE?

Jamal Azfar Khan, Muhammad Rizwan Bashir Kiani, Khawar Shabbir, Mohsin Qayyum.

Abstract
Objective: Acute Mountain Sickness is a common condition encountered at high altitude. Many treatment modalities have been used to treat it, including acetazolamide and dexamethasone. The data regarding any added benefit of combining the two drugs is scarce.
Study Design: Prospective randomized controlled trials.
Place and Duration of Study: To compare the response of patients of Acute Mountain Sickness (AMS) treated with acetazolamide and dexamethasone with those treated with acetazolamide alone.
Material and Methods: A total of 76 consecutive patients of AMS were included in the study at Goma (3300 meters). They were assigned randomly to two groups: group 1 treated with acetazolamide and dexamethasone, and group 2 treated with acetazolamide only. Their progress was noted at 12, 24, 36 and 48 hours.
Results: At 3300 meters, the rate of recovery of patients of AMS treated with Acetazolamide and Dexamethasone was not different from that of those treated with Acetazolamide alone.
Conclusion: The response of patients of AMS treated with acetazolamide and dexamethasone is the same as those treated with acetazolamide alone.

Key words: Acetazolamide, Altitude, Altitude sickness, Dexamethasone.


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