Abstract

Click chemistry is nowadays a versatile strategy for obtaining new bioactive compounds for different diseases, including cancer. Click strategy-based synthetic approaches offer effective routes for the rapid and mild production of bioactive compounds. Triazole ring is known to have significant pharmaceutical value because its derivatives have been shown to have a variety of pharmacological actions, including cancer. There are numerous techniques for triazole ring construction, but click chemistry offers a quick, selective, and dependable approach. The reaction of an azide with a terminal alkyne based on the CuI-catalyzed Huisgen 1,3-dipolar cycloaddition to create 1,2,3-triazoles is the most frequent reaction in click chemistry. The resulting triazole ring is essential in the composition of some clinically approved drugs and other compounds with strong anticancer effects since this fragment may help to improve selectivity, optimize pharmacokinetic features, and overcome resistance. This work shows a bibliometric analysis of published studies on click chemistry and their application in the synthesis of hybrid and conjugate molecules with anticancer activity. Also, we revealed that molecular docking showed the possible mechanism of action of some compounds. Furthermore, bibliometric analysis is shown, providing a holistic overview of the areas in which click chemistry investigations have been focused. Chemistry, materials science, chemical engineering, pharmacology, toxicology and pharmaceutics, and biochemistry, genetics, and molecular biology were the primary fields of study in the field. Finally, the findings show that there has been a notable increase in study on click chemistry, its hybrids, and conjugates, with molecular docking simulations emerging as a new field.

Key words: Click Chemistry, triazole, hybrids, anticancer activity, bibliometric analysis