| Original Research | 
|  |
RMJ. 2026; 51(2): 552-556 Phytochemical interventions against interleukin-6 (il-6) in covid-19: a novel computational approach to T cell recoveryArif Malik, Anoosh Qayyum, Jehanzaib Islam, Gul Zaib, Haleema Saadia, Ayesha Zahid. Abstract |  Download PDF | |  Post | Objective: To assess the ability of anti-inflammatory phytochemicals to suppress IL-6 production and restore T cell homeostasis.
Methodology: We tested 15 phytocompounds protein-ligand docked and the best three were chosen for study. Swiss modeling employed homology modeling to predict 3D structure and ITASSER for cross validation.
Result: Wedelolactone, Catechin, and Quercetin interact strongly with the targeted protein IL-6 in In-Silico molecular docking experiments. All top 3 phytocompounds predicted IL-6 active sites with low binding energies and strong affinity (-7.3 to -7.8 kcal/mol). Phytocompounds' drug-likeness, ADMET profiles, and toxicity predictions were promising.
Conclusion: IL-6 projected structure is trustworthy for corona virus structural and functional research. The anticipated binding locations may help build new corona virus-fighting drugs.
Key words: COVID-19, interleukin-6, molecular docking, SwissADME, ProTox-3.0.
|
Bibliomed Article Statistics 7
 | R
E
A
D
S |
3
| D
O
W
N
L
O
A
D
S | | 05 | | | 2026 | |
|
|
|
|
