This study was undertaken to evaluate the in vivo anti-diarrhoeal activity of methanolic stem bark
extract of Dialium guineense used traditionally as remedy for gastrointestinal disorder in South-
Western Nigeria. The effect of the extract at oral dosesof 50-200 mg/kg body weight on the castor
oil-induced diarrhoea, gastrointestinal motility (charcoal meal) and castor oil-induced intestinal
fluid accumulation (enteropooling) were examined in rats. The extract employed produced a dose dependent
and significant (P
Key words: Diarrhoea, Dialium guineense, intestinal transit, antisecretory, loperamide
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