Gymnemic acid is obtained from the natural resource and has got antioxidant property, was investigated for the possible neuroprotective effect in experimentally induced cerebral ischemic rats. Carotid arteries clamped with the help of aneurysm clips to produce cerebral ischemia, the clips were removed from the arteries to allow the reflow of the blood through carotid arteries. It was observed that lipid peroxidation was increased significantly after bilateral common carotid artery occlusion. Brain endogenous antioxidant GSH and total protein levels were low. Administration of gymnemic acid in a dose of 250 mg/kg and 500 mg/kg b.w orally showed promising neuroprotective effect by reducing cerebral infarct size as well as improved all antioxidant levels showing activity against oxidative stress
Key words: Gymnemic acid, BCCAO, neuroprotective, oxidative stress, acetyl cholinesterase
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