Home|Journals|Articles by Year|Audio Abstracts RSS - TOC

J App Pharm Sci. 2016; 6(6): 055-060

In vitro trypanocidal activity of the Egyptian plant Schinopsis lorentizii against trypomastigote and amastigote forms of Trypanosoma cruzi

Khaled Rashed, Daniele Da Silva Ferreira, Viviane Rodrigues Esperandim, Maria Gabriela Marçal, Breno Mumic Sequeira, Luzio Gabriel Bocalon Flauzino, Wilson Roberto Cunha.


Chagas’ disease is a chronic illness caused by the protozoan Trypanosoma cruzi. According to estimates, approximately 16-18 million people are infected in Latin American. Plant extracts exhibit a wide variety of secondary metabolites and can play an important role in the discovery of new compounds with biological potential. The in vitro trypanocidal activity of the extracts obtained from six plant species collected in Egypt (Parkia africana, Parkia roxburgi, Lagerstromeia speciosa, Schinopsis lorentzii, Lagerstromeia indica, and Sapindus saponaria) was assayed against trypomastigote and amastigote forms of T. cruzi. The cytotoxic activity of the most active extract was also evaluated by conducting MTT assays. S. lorentzii and S. saponaria were the most active extracts against the trypomastigote form; IC50 values were 9.9 and 27.34 g/mL, respectively. The S. lorentzii extract was also evaluated against the amastigote form (IC50 was 111.5 g/mL). The S. lorentzii extract did not exhibit significant cytotoxic activity. The selectivity index value indicated that this extract was highly selective for the parasite. The S. lorentzii and S. saponaria extracts exhibit trypanocidal activity, probably as a result of the presence of different constituents and their concentrations in the extracts.

Key words: Egyptian medicinal plants, trypanocidal activity, Trypanosoma cruzi, phytoconstituents

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.