Home|Journals|Articles by Year

Directory for Medical Articles
 

Original Article

Natl J Community Med. 2015; 6(4): 487-490


Interplay of Serum Erythropoietin and Inflammatory Cytokine in Anemic Tuberculosis Patients

Rashmi Anant Kulkarni, Ajit Ramesh Deshpande, Kiran Saxena.


Abstract

"Introduction- As tuberculosis is a chronic infectious disease the anemia of inflammation may contribute significantly in pathophysiology of anemic tuberculosis patients so this study was carried out to find out the role of Tumor Necrosis Factor alpha (TNF α) and serum erythropoietin (EPO) in anemic tuberculosis Patients.
Material & Methods - The study comprised of sixty-eight anemic pulmonary tuberculosis patients. Levels of Heamoglobin ( Hb), serum Iron, serum erythropoietin & serum TNF α were analyzed in all of them.
Result- The inflammatory parameter TNF α along with serum erythropoietin was found to be increased in anemic tuberculosis patient and levels of Hb, iron was decreased. Hemoglobin showed fair degree of linear relationship with TNF levels (r = -0.273). Heamoglobin and erythropoietin did not show linear or inverse correlation with each other(r= 0.161). Iron showed negative but non linear correlation with TNF & EPO levels(r= -.128 & -0.042 ). TNF and erythropoietin showed inverse but non linear correlation with each other ( r= -0.100).
Conclusion - Insufficient response of erythropoietin to the degree of anemia was found and an increased level of tumor necrosis factor was probably the contributing factor in induction of anemia in tuberculosis patients.
"

Key words: Anemia of chronic diseases, erythropoietin, Tumor Necrosis Factor alpha






Full-text options


Share this Article



Online Article Submission
• ejmanager.com
• ojshosting.net







Do you want to use OJS for your journal ?
work with an experienced partner
www.OJSHosting.net

eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.